Reproduction Abstracts

Sertoli cells (SC) are key initiators of testis development and have a fundamental role in spermatogenesis. However, it is uncertain how an acute reduction in SC number, in a hormone independent-manner at key points in development or adulthood, will impact testis function.To induce acute SC-ablation at key points of testicular development, we used Cre-loxP recombinase technology and the expression of Diphtheria toxin and its receptor. We utilized these l...